How is true diabetes insipidus and nephrogenic diabetes insipidus diagnosed?
Diabetes mellitus and diabetes insipidus share the first word of their name and some of the same symptoms. But that’s where the similarities end. These two diseases aren’t related. They cause different problems and have very different treatments. Show
Diabetes mellitus is more commonly known simply as diabetes. It’s when your pancreas doesn’t produce enough insulin to control the amount of glucose, or sugar, in your blood. Diabetes insipidus is a rare condition that has nothing to do with the pancreas or blood sugar. Instead, it happens when your kidneys produce a lot of extra pee. Normally, they filter your bloodstream to make about a quart or 2 each day. When you have diabetes insipidus, it’s more like 3 to 20 quarts, and it’s mostly water. This dramatic loss of fluid makes you really thirsty. Symptoms of EachThough diabetes mellitus and diabetes insipidus have similar symptoms, these symptoms have different causes. Exhaustion: With diabetes insipidus, you may feel extremely tired due to dehydration. It also may be because you’re low on electrolytes, such as sodium, potassium, or calcium, which get flushed out with all the pee. If you have diabetes mellitus, you may feel really tired when your blood sugar levels are either too low or too high. Thirst: Diabetes insipidus makes you feel very thirsty because so many fluids are leaving your body. With diabetes mellitus, you feel thirsty because of too much glucose in your blood. Your body wants you to drink more water to flush out the sugar. Blurred vision: Long periods of dehydration can lead to blurry vision if you have diabetes insipidus. With diabetes mellitus, it’s because you have too much glucose in your blood. How Are They Diagnosed?There are a few blood tests to diagnose diabetes mellitus. One is the fasting glucose test. This is when a doctor draws blood after you haven’t eaten for at least 8 hours. The other test is the A1c, or glycated hemoglobin test. You don’t have to fast for this one. Your scores will determine if your doctor may diagnose you with either prediabetes or diabetes. Doctors also diagnose diabetes insipidus in several ways: Blood test: Instead of glucose, this blood test measures your sodium levels. Urinalysis: This test shows how concentrated or dilute (watery) your pee is. Your doctor might even ask you to collect it for 24 hours to see how much you make in that time. Fluid deprivation test: There are two types: a short form of the test you can do at home and a longer one you do in the hospital. For the short test, your doctor will tell you to stop drinking fluids at a certain time, often dinnertime. The next morning, you’ll collect a urine sample and take it to your doctor. For the longer fluid restriction test, you’ll be in the hospital. A doctor will weigh you and take a urine sample. They’ll repeat those steps every 1-2 hours while you don’t drink fluids. They’ll also take your blood pressure. They’re looking for one of three things to happen:
Magnetic resonance imaging (MRI): An MRI can’t diagnose diabetes insipidus. But it can show problems with your hypothalamus or pituitary gland. These issues can cause the disease. They can be because of a gene mutation or damage from a head injury, surgery, infection, or a tumor. The damage upsets the way these parts of your brain make, store, and release vasopressin. This is a hormone that helps your kidneys absorb water and control the flow of urine. How Are They Treated?There’s no cure for diabetes mellitus or diabetes insipidus, but you can manage them. If you have type 1 or type 2 diabetes, you’ll usually manage your blood sugar with insulin shots or other medications. Check it daily to make sure it’s in a safe range. You’ll need to eat a healthy diet and get regular exercise to keep your weight, cholesterol, and blood pressure down. See your doctor for regular checkups. Diabetes Insipidus Written by Matthew Hoffman, MD Medically Reviewed by Minesh Khatri, MD on June 19, 2022 In this Article
Diabetes insipidus is a rare condition that causes you to have an almost unquenchable thirst and your body to make a lot of urine that is colorless and odorless. Most people pee out 1 to 2 quarts a day. People with diabetes insipidus can pass between 3 and 20 quarts a day. The main types of diabetes insipidus include central, nephrogenic, and pregnancy-related. Diabetes insipidus is a different disease from diabetes mellitus. Their names are similar, but the only things they have in common is that they make you thirsty and make you pee a lot. If you have diabetes insipidus, the hormones that help your body balance liquids don’t work. Only one in every 25,000 people gets this condition. With diabetes mellitus (often shortened to “diabetes”), your body can’t use energy from food like it should. It’s far more common. Around 100 million Americans have type 1 or type 2 diabetes. Symptoms of Diabetes InsipidusSymptoms include:
With dehydration, you might notice:
Symptoms in Infants and ChildrenMany of the symptoms are similar in younger people. In infants, watch for:
In children, signs include:
Diabetes Insipidus CausesYour body makes a hormone called vasopressin in a part of your brain called the hypothalamus. It’s stored in your pituitary gland. Vasopressin tells your kidneys to hold on to water, which makes your urine more concentrated. (Vasopressin is also called antidiuretic hormone or ADH.) When you’re thirsty or a little dehydrated, your vasopressin levels go up. Your kidneys absorb more water and put out concentrated urine. If you’ve had enough to drink, vasopressin levels fall, and what comes out is clear and diluted. When your body doesn’t make enough vasopressin, the condition is called central diabetes insipidus. Anyone can get central DI, but it's not common. Only about 1 in every 25,000 people gets it. If you make enough but your kidneys don’t respond to it the way they should, you have nephrogenic diabetes insipidus. In either form, the result is the same. Your kidneys can't keep water, so even if you’re dehydrated, they'll put out a lot of pale urine. Changes in the genes that you inherit from your parents can make you more likely to get diabetes insipidus. This happens in 1% to 2% of cases. Your doctor will do a physical exam. A checkup may not show any signs of central DI, except maybe an enlarged bladder or symptoms of dehydration. They’ll ask questions about your health history, including your family’s health. You might get a series of tests that include:
Diabetes insipidus that isn’t under control can make you more likely to have complications like: First, your doctor will tell you to drink plenty of fluids. That will replace the constant loss of water. Other treatments depend on which type you have: Diabetes insipidus doesn’t cause kidney failure or lead to dialysis. Your kidneys still do their main job, which is to filter your blood. But you will be more prone to dehydration. Make sure you always have something to drink close by, especially when it’s hot or when you exercise. Carry your medication with you, and avoid situations where you can't get water. It's also a good idea to wear "medic alert" jewelry, or keep a note with you about your condition, so that health care workers know about it. SOURCES: eMedicine: "Diabetes Insipidus." MedicineNet: "Diabetes Insipidus." Nephrogenic Diabetes Insipidus Foundation: "NDI Facts and Statistics." Diabetes Insipidus Foundation: "What Is Diabetes Insipidus?" "The 4 Types of DI." The National Institute of Diabetes and Digestive and Kidney Diseases: “Diabetes Insipidus,” “Diabetes Statistics.” |