Which medication classification is known to inhibit prostaglandin synthesis or release?
Each tablet of ARCOXIA for oral administration contains either 60, 90 or 120 mg of etoricoxib. Show Therapeutic Class: ARCOXIA (etoricoxib) is a member of a class of arthritis/analgesia medications called Coxibs. ARCOXIA is a highly selective inhibitor of cyclooxygenase-2 (COX-2). ARCOXIA is indicated for: Acute and chronic treatment of the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA). ARCOXIA is administered orally. ARCOXIA may be taken with or without food. ARCOXIA should be administered for the shortest duration possible and the lowest effective daily dose should be used. In clinical studies, administration of ARCOXIA at single doses up to 500 mg and multiple doses up to 150 mg/day for 21 days did not result in significant toxicity. There have been reports of acute overdosage with etoricoxib, although adverse experiences were not reported in the majority of cases. The most frequently observed adverse experience were
consistent with the safety profile for etoricoxib. (e.g. gastrointestinal events, renovascular events).
ARCOXIA is contraindicated in patients with: Hypersensitivity to any component of this product. RISK OF GI
ULCERATION, BLEEDING AND PERFORATION WITH NSAIDs: Serious GI toxicity such as bleeding, ulceration and perforation can occur at any time, with or without warning symptoms, in patients treated with NSAIDs therapy. Although minor upper GI problems (e.g. dyspepsia) are common, usually developing early in therapy, prescribers should remain alert for ulceration and bleeding in patients treated with NSAIDs even in the absence of previous GI tract symptoms. Clinical trials
suggest that the selective COX-2 inhibitor class of drugs may be associated with an increased risk of thrombotic events (especially MI and stroke), relative to placebo and some NSAIDs (naproxen). As the cardiovascular risks of selective COX-2 inhibitors may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used. The patient's need for symptomatic relief and response to therapy should be re-evaluated periodically. Pregnancy: The use of etoricoxib, as with any drug substance known to inhibit COX-2, is not recommended in women attempting to conceive. No clinical data on exposed pregnancies are available for etoricoxib. Studies in animals have shown reproductive toxicity. The potential for human risk in pregnancy is
unknown. Etoricoxib, as with other medicinal products inhibiting prostaglandin synthesis, may cause uterine inertia and premature closure of the ductus arteriosus during the last trimester. Etoricoxib is contraindicated in pregnancy. If a woman becomes pregnant during treatment, etoricoxib should be discontinued. In clinical trials, ARCOXIA was evaluated for safety in 9295 individuals, including 5774 patients with OA, RA or chronic low back pain (approximately 600 patients with OA or RA were treated
for one year or longer). Warfarin: In subjects stabilized on chronic warfarin therapy, the administration of ARCOXIA 120 mg daily was associated with an approximate 13% increase in prothrombin time International Normalized Ratio (INR). Standard monitoring of INR values should be conducted when
therapy with ARCOXIA is initiated or changed, particularly in the first few days, in patients receiving warfarin or similar agents. Store at 30°C (86°F). Protect from moisture and light. M01AH05 - etoricoxib ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, coxibs. FC tab 60 mg (dark green apple-shape biconvex debossed ARCOXIA 60 on one side and 200 on the other side) x 100's. 90 mg (white apple-shape biconvex debossed ARCOXIA 90 on one side and 202 on the other side) x 30's, 100's. 120 mg (pale green apple-shape biconvex debossed ARCOXIA 120 on one side and 204 on the other side) x 30's. What are some medications that affect prostaglandins?Medications. Bimatoprost (Lumigan, Latisse). This is a medication used to treat glaucoma as well as to promote eyelash growth.. Carboprost (Hemabate). This medication produces uterine contractions that may help reduce postpartum bleeding.. Dinoprostone (Cervidil). ... . Misoprostol (Cytotec). ... . Latanoprost (Xalatan).. What drug inhibits the production of prostaglandins in order to reduce fever?NSAIDs block COX enzymes and reduce production of prostaglandins. Therefore, inflammation, pain, and fever are reduced.
What medication inhibits prostaglandin synthesis?Aspirin and a large number of nonsteroidal anti-inflammatory drugs act primarily through the inhibition of prostaglandin synthesis by inhibiting the enzyme cyclooxygenase.
Which of the following analgesics acts by inhibiting prostaglandin synthesis?Acetaminophen. Acetaminophen inhibits the synthesis of prostaglandins that may serve as mediators of pain and fever primarily in the CNS. Acetaminophen is used to treat mild pain and fever; however, it does not have anti-inflammatory properties.
|